Comera Investor Presentation Deck

mAb liquid formulation development using SQore excipients Viscosity (cps) CS1+ CS2 CS1+ CS3 CS1+CS5 100.00 90.00 80.00 70.00 60.00 50.00 40.00 30.00 20.00 10.00 0.00 50 Contral C51-CSS No stab control A CS1+ CS2 ●CS1.CS3 70 Excipient combination No stabilizer No viscosity reducer 90 110 130 150 conc (mg/ml) 170 190 Monomer stability 40C 52.19 58.63 85.21 20 87.3 210 230 250 Viscosity at 150 mg/ml 32.05 38.21 20.25 13.5 54.38 % monomer remaining 100 80 g 60 40 20 0 Viscosity(Cp) 60 50 40 30 20 10 O Compiled best stabilizer mixes 40C data no stab 0 ul CS1+ CS3 CS1+ CS2 Stabilizer mixtures 20 40 CS1+ CSS Stability 60 #4 wks Comera LIFE SCIENCES High stability + low viscosity 80 100 19

View entire presentation