Conference Presentation

Tobacco Is A Massive Market Opportunity 4% 3% 4% 2% 0.3% Global Tobacco Market 2018 ¹ $817B $714B¹ 87% Cigarettes Cigars & Cigarillos Smoking Tobacco ↑ Smokeless Tobacco Vaping Systems & Heated Tobacco Products NRT Smoking Cessation Aids 60% of current adult smokers indicated likelihood to use VLNⓇ 1B Global Adult Smokers 2 2/3 of Adult Smokers Want to Quit 4 <10% of Adult Smokers Successfully Quit in 2018 4 1) Foundation for a Smoke Free World; https://www.smokefreeworld.org/wp-content/uploads/2019/08/FSFW Global-Trends-in-Nicotine 6.22.2020.pdf 2) World Health Organization; https://www.who.int/gho/tobacco/use/en/#:~:text=In%202015%2C%20over%201.1%20billion, Region%20and%20the%20African%20Region. 3) Centers for Disease Control and Prevention; https://www.cdc.gov/tobacco/data statistics/fact sheets/adult data/cig smoking/index.htm 4) Centers for Disease Control and Prevention; https://www.cdc.gov/tobacco/data statistics/fact sheets/cessation/smoking-cessation-fast-facts/index.html 5) U.S. News; https://health.usnews.com/health-conditions/allergy-asthma-respiratory/smoking-cessation/overview Ž 34M U.S. Adult Smokers 3 SMOKERS ARE ACTIVELY SEEKING ALTERNATIVES TO ADDICTIVE COMBUSTIBLE CIGARETTES 22nd Century Group, Inc. 1/2 of Adult Smokers Made an Attempt to Quit in the Past Year 4 95% of smokers Who Do Not Participate in a Smoking Cessation Program Fail 5 10

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