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SeaSpine Investor Update

$ 15-18% 3-year Revenue CAGR om 150BPS Commission Leverage by 2024 (vs. 2019) S $300- $320M Annual Revenue Threshold for Adj. EBITDA Breakeven (exiting 2024) 10% R&D Expense as % of Total Revenue in 2024 Q >500BPS Adj. GM % Expansion by 2024 $ >50% Reduction in Free Cash Flow Burn by 2024 Ⓒ2022 SeaSpine Orthopedics Corporation. All rights reserved | 22 Guidance Long-Term Financial guidance information is as of August 2, 2022, based on guidance provided by SeaSpine leadership on that date. Inclusion of this information in this presentation is not a confirmation or an update of, and should not be construed or otherwise assumed to reflect any confirmation or update of, that guidance by SeaSpine leadership as of any date other than August 2, 2022. SeaSpine
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