Investor Presentation

15 X DiscoverX BioMAP® system measures effect on human cellular functions 4H: VEGFR2 LPS: MCP-1 LPS: VCAM-1 LPS: Thrombomodulin LPS: Tissue Factor LPS: CD40 LPS: E-Select LPS: CD 9 LPS: I-8 LPS: IL 1a LPS: M-CSF LPS: SF GE2 LPS SRB LPS: STNF-a SAg: MCP-1 SAg CD38 SAg CD40 SAG: E-electin SA CD69 SA: IL-8 Sg: MIG SAg: PBMC Cyt toxicity SAg: Proleration SA: SRB BT: B-cell Proliferation BT: PBMC Cytoxicity BT: Secreed IgG BT: S-17A BT:sl-17F BF4T: MO-1 BF4T: Eotaxi-3 BF4T: VCAM 1 BF4T ICAM BF4T: CD9 20 BF4T: IL- BF4T: IL-1a BF4T: Keratin 8/18 BF4T: MMP-1 BF4T: MMP-3 BF4T: MMP-9 BF4T: PAI- BF4T: SRB BF4T: IPA BF4T: UPA BE3C: ICAM-1 BE3C: UPAR BE3C: IP-10 BE3C:I-TAC BE3C: IL-8 BE3C: MIG BE3C: EGFR BE3C: HLA-DR BE3C: IL-1a Keratin 8/18 BE30 MMP-1 ESC: M BE3C: MMP- BE3C: PAI BE3C: SRB BE3C: IPA BE3C: UPA CASM3C: MCP-1 HDF3CGF: VCAM-1 HDF3C GF: ICAM-1 HDF3CGF: Collagen i DF3C GF: Collagen III HDF3CGF: IP-10 HDF3CGF: 1-TAC HDF 3CGF: IL-8 HDF3CGF: MIG HDF 3CGF: EGFR HDF3CGF: M-CSF HDF3CGF: MMP-1 HDF3CGF: PAL-I HDF3CGF: Proliferation 6 HDF3CGF: SRB HDF3CGF: TIMP-1 HDF3CGF: TIMP-2 KF3CT: MCP-1 KF3CT: ICAM-1 KF3CT. IP-10 KF3CT: IL-8 KF3CT: MIG KF3CT: IL-1a KF3CT: MMP-9 KF3CT: PAI-I KF3CT: SRB KF3CT: TIMP-2 KF3CT: T: UPA MyoF: a-SMA MyoF: bFGF MyoF: VCAM-1 MyoF: Collagen I MyoF: Collagen III MyoF: Collagen IV MyoF: IL-8 MyoF: Decorin MyoF: MMP-1 MyoF: PAI- MyoF: SRB MyoF: TIMP-1 IMphg: MCP-1 Xeljanz™ 0.37μµ >$1bn Esbriet™ 1700μ >$800mn Ofey™ TM 1.1μ >$1bn Actemra™ 100μ >$1bn Lenabasum 3.3μ Drug Conc. N/A $/yr Activation Monocyte Activation T cell Activation B cell Epithelial Inflammation and Remodeling Fibrosis and Inflammation Wound Healing, Matrix and Tissue Remodeling, Decreased Increased cell activation suppressing immune Lenabasum is not IMMUNOSUPPRESSION epithelial cells of inflammatory mediators by Lenabasum reduces production EPITHELIAL INFLAMMATION FIBROSIS matrix by connective tissue cells Lenabasum reduces production of inflammatory mediators and extracellular Advantages Over Commercial Anti-Inflammatories. Lenabasum In Vitro Profiling Suggests Lenabasum

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