BioNTech Results Presentation Deck

BNT113: Potential to Increase Response Rate and DoR to CPI by Stimulating Immune Response Against HPV16 Proteins BNT113 encodes HPV16 oncoproteins E6 & E7 • E6 and E7 proven to be well-suited for immunotherapy intervention ● ● ● Exclusively expressed in pre-malignant and malignant tissue Maintain the transformed state of infected malignant cells Demonstrated immunogenicity Not affected by central tolerance mechanisms 27 5' HPV, human papilloma virus; DoR, Duration of Response, CPI, check point inhibitor 5' HI HPV-E6 HPV-E7 BNT113 combination with anti-PD1: Potential for synergistic antitumor effect delaying escalation to toxic chemo H AAAA Poly(A) tail AAAA BIONTECH

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