Bionomics IPO Presentation Deck

BNC210 Anti-Anxiety Signals Observed in Animal Models and Human Translational Studies of @ People with anxiety disorders and PTSD have amplified fear responses to trauma-or stress-related stimuli and impaired fear extinction Time Spent Freezing (sec) G Conditioned Fear Extinction Model 175 150- 125- 100- 75- 50 25- 10 T T Diazepam (0.5 mg/kg) Vehicle BNC210 (100 mg/kg) p=0.03 p = 0.01 Days after Conditioning BNC210 enhanced fear extinction following conditioned response training "Time in minutes ofter CC-4 injection Bionomics CCK-4-Cholecystokinin Tetrapeptide to peptide that induces anxiety and ponic symptoms) eMAS = Emotional Visual Analog Scole eVAS Score Emotional Visual Analog Scale (eVAS) 10 -10 -20 -30 Recovery to Baseline OBNC210 1 5 10 15 20 60 Placebo Recovery to Baseline 5 10 15 20 60 Minutes (Post-Panic Attack)* BNC210 enhanced emotional recovery following a CCK-induced panic attack 18

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