Connecting Innovation to Purpose

Best Percent Change from Baseline in Sum of Diameters (%) Phase 1 Dose Escalation - Disease Response 19 90 60 30 0 -30 -60 -90 DOSE mg/kg INDICATION NECTIN-4 PD 46.60 PD 28.57 PD 25.66 1.2 1.8 2.7 TNBC TNBC CRC 70 167 140 PD 24.69 3.6 UC PD 16.95 SD 0.00 SD -0.86 PD -0.95 SD -2.27 0.6 1.2 3.6 1.8 0.6 TNBC Cervical Breast UC Cervical 123 110 25 65 68 SD -2.70 2.7 UC 105 PD -7.50 0.2 UC 80 SD SD -23.33 -24.42 PR -30.46 PR -35.62 PR -39.81 1.8 3.6 3.6 0.6 2.7 UC Cervical Cervical Cervical UC 92 235 185 190 65 TNBC Breast CRC Cervical UC PR -64.22 1.2 UC 175 Disease response in 3.6 mg/kg and 2.7 mg/kg doses: ORR 43% DCR 71%

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