Taysha IPO Presentation Deck

Adult polyglucosan body disease (APBD) is a progressive, "prime of life" illness - APBD is caused by reduced glycogen branching enzyme (GBE1) activity GBE1 mutations lead to uncontrolled glycogen elongation and the formation of polyglucosan bodies Symptoms include sensory loss in the legs, progressive muscle weakness, gait disturbances, urinary difficulties, and mild cognitive impairment - The estimated prevalence of APBD is 1,000 patients in the US and EU AAV9+ DAT hGBE1 Intrathecal delivery 444 ch * 54

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