Kymera IPO Presentation Deck

IRAK4 Biology and Degrader Rationale • IRAK4 is a key component of myddosome protein complex Myddosome involved in innate immunity that mediates signals through IL-1R and TLRs • IL-1R/TLR signaling through the myddosome complex is dependent on IRAK4 kinase and scaffolding functions • Degrading IRAK4 we believe can provide a single oral small molecule solution to many diseases impacted by this pathway KYMERA Indications/Timeline AD, Hidradenitis Suppurativa (HS), RA Current: IND enabling studies Expected IND submission: 1H 2021 Expected P1: 1H 2021 Kinase Domain IL-1 Family Cytokines: IL-1a/B, IL-18, IL-33, IL-36 IL-1R KINASE DEPENDENT Inhibitor IRAKA Kinase Catalytic Activity JNK/p38 Cytokines MyDB8 IRAK4 T IRAK4 Degrader T TLRs Scaffolding NFkB TLR Agonists KINASE INDEPENDENT Death Domain

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