Akouos IPO Presentation Deck

Diagnosis of Hearing Loss Soft Hearing Loss (dB HL) Loud NORMAL MILD MODERATE MODERATELY- SEVERE SEVERE PROFOUND Low Pitched 125 i md b 250 ng Y 500 E 1000 2000 Frequency (Hz) High Pitched feth 4000 8000 An individual with this audiogram would be unable to hear sounds at lower dB levels above the circles and Xs AKOUOS • Clinical diagnosis of sensorineural hearing loss depends on the demonstration of reduced hearing sensitivity by auditory testing Children with Severe to Profound hearing loss cannot perceive typical speech sounds and are unlikely to develop verbal language • Hospitals typically use either ABR or otoacoustic emission (OAE) testing to identify hearing loss in newborns ▪ ABR testing reflects how the cochlea, auditory nerve, and auditory pathways in the brain are working CONFIDENTIAL OAE testing reflects whether outer hair cells in the cochlea respond to sound

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