Bionomics IPO Presentation Deck

A Differentiated Approach: The a7 Nicotinic Acetylcholine Receptor 3 Normalizing Effect Utilizing Allosteric Modulation 2 1 Channel opens: ACh binds to a7 receptor orthosteric sites 00000 PAMS/NAMS bind to a7 receptor allosteric sites Bionomics Ca Poooooooooo Ca² Co-Calcium ACH- Acetylcholine NAM-Negative Aloten Modulator PAM-Positive Asteric Modulator Ca²+ flow through the channel when CAS-Cognitive impament Associated with Schumphrenic JONO Attention Date a7 receptors are activated Transmembrane Binding Domain Allosteric drug transmembrane binding domain restores normal activity Cholinergic System associated with memory selective attention, and emotional processing cognitive functions PTSD-Post-Traumotic Stress Disorder Targeting Distinct CNS Conditions with Neurotransmitter Imbalance Hypercholinergic Disease States PAM Indications +Alzheimer's Bionomics NORMAL ACTIVITY + CIAS + ADHD BNC210 (NAMS) + Anxiety + PTSD + Depression 7 Hypocholinergic Disease States

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