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Developing proof of concept for novel RNA-based approach to gene therapy
Initial research into promising new avenue for Sickle Cell therapy with grant from the Bill & Melinda Gates Foundation
RNA-encoded instructions
ww
Target specific vehicle
ww
Target
m
GreenLight gene therapy
architecture targeting
potential solutions that:
Ribosome
MM
Target cell
Can edit dividing and nondividing cells
Do not require viral vectors
Achieves long-lasting effect
Are delivered direct to the patient
Can be manufactured at scale
Investor Presentation 2021 GreenLight Biosciences. All rights reserved. GreenLight confidential.
Cell
Nucleus
Long lived
expression of
wild-type beta-
globin gene
Proprietary
approach for
integration of wild-
type beta-globin
gene
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