Taysha IPO Presentation Deck

Efficacy: TSHA-102 outperformed unregulated AAV9/mini in MECP2 KO mouse survival study % Survival 100 80 60 40 20 0 0 5 10 15 20 25 Age (weeks) Mice were dosed P28-35 Diamond = vet-requested euthanasia, primarily for lesions. Lesions have been observed with varying frequencies among saline-treated KO mice, virus-treated WT and KO mice, as well as untreated RTT weanlings. WT, 0 vg, n=13 KO, 0 vg, n=18 KO, 1x10¹2 vg AAV9/MECP2(v2), n=12 KO, 1x10¹2 vg AAV9/mini, n=12 KO, 1x10¹2 vg TSHA-102, n=12 30 35 00 36

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