Ocuphire Pharma Investor Presentation Deck

Progression Based on DR Severity NPDR Patients are Rarely Treated with anti-VEGF Intravitreal Injections; Non-Invasive, Early Intervention is an Unmet Need Ocuphire Percentage of Eyes that Worsen to PDR 100% 80% 60% 40% 20% 0% Regardless of severity, all eyes worsen over time 5% 14% 25% 12% 30% Mild NPDR (35) Moderate NPDR (43) 40% 26% 48% 66% Moderately Severe NPDR (47) 52% 71% 80% Severe NPDR (53) 5 Year Follow-up 3 Year Follow-up 1 Year Follow-up Spherix Global Insights: DR Market DYNAMIX October 2022 Early treatment diabetic retinopathy study research group. ophthalmology. 1991;98(5 suppl):823-33. Diabetes control and complications trial research group. N Engl J Med. 1993;329(14):997-86. Fathy C, Patel S, Sternberg P Jr, Kohanim S. Disparities in adherence to screening guidelines for diabetic retinopathy in the United States: a comprehensive review and guide for future directions. Semin Ophthalmol. 2016;31(4):364-377. doi: 10.3109/08820538.2016.1154170 9

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