First Quarter 2017 Financial Review

Interest Rate Sensitivity Significant upside from rate increase Additional Annual Net Interest Income¹ Estimate over 12 months following interest rate movement Deposit Beta Assumptions Rate Increase 0% Next +25 bps Mar '17 +25 bps Dec '16 ~$85MM +25 bps 25% ~$70MM 0-75% ~$40MM to ~$85MM Why is Comerica Asset Sensitive? 90% of loans are floating rate & reprice quickly Fixed rate securities < 20% of earning assets Non-maturity noninterest bearing deposits are 54% of deposit base 1.70% 1.45% 1.20% 0.95% 0.70% Fed Funds Futures² Jul-19 Oct-19 Jan-20 Outcome may vary due to a number of variables including balance sheet movements (loan & deposit levels as well as incremental funding needs) Apr-17 Jul-17 Oct-17 Jan-18 Apr-18 Jul-18 Oct-18 Jan-19 Apr-19 3/31/17 Outlook as of 4/18/17 Based on immediate parallel shock. Assumes 25 bps increase in Fed Funds, Prime & LIBOR. Calculations derived from sensitivity results shown on slide 19 ⚫2Source: Bloomberg as of 4/17/17 Comerica Bank Ⓡ 13 GEAR Up: Growth in Efficiency And Revenue On Track to Reach FY18 Target: ~$270MM additional annual pre-tax income¹ GEAR Up: 2017 Focus Continue to gain efficiencies even as rates rise & economy improves Revenue enhancements Standardize training Launch new Customer Relationship Management platform Roll-out share of wallet analysis Rationalize & modernize IT applications Expand operational process automation Optimize infrastructure platforms End-to-End Credit Workforce Reduction (# of employees - full time equivalent) Revised Retirement Plans³ 8,880 7,960 8,044 -8,000 58 ($ in millions) 16 (17) 2015 2016 1Q17 Proj 2017 2015 2016 Proj 2017 Banking Centers² Real Estate (sq. ft. in millions) 476 457 438 5.18 4.96 -4.70 Simplify governance process Introduce new technology to support digital approach 2015 2016 Proj 2017 2015 2016 Pool back office resources across all markets Proj 2017 Relative to when we began the initiative in June 2016 ⚫2Count of total U.S. banking centers Includes Pension, Postretirement & Retirement Account Plan costs Estimates & outlook as of 4/18/17 Comerica Bank Ⓡ 14

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