Kymera IPO Presentation Deck
Jo
KYMERA
Whole-Body
Toolbox
Ternary
Complex
Modeling
Quantitative
System
Model
Proprietary
Chemistry
Utilize comprehensive strategies for identification of starting ligands that bind to E3 ligases and proteins of interest
Identify compounds with preferred physiochemical properties conducive to achieving the optimized target product profile
• In silico drug discovery to accelerate hit finding and optimization
Readily accessible and diverse library of preferred linkers to connect binders to the E3 ligase and the target
Enables rational degrader design and optimization, and ability to improve molecular properties
Characteristic
V Pegasus
Proprietary Chemistry
Potency
Human in vitro clearance
Membrane permeability
In vivo clearance
Bioavailability
Metric
Whole Blood IRAK4 DC (nM)
HLM (mL/min/mg)
Permeability (A/B; x10 cm/s)
Mouse CL (mL/min/kg)
Mouse PO PK (%F)
Compound A
(1 Generation)
280
96
0.4
177
Compound B
(2nd Generation)
17
3
<-15
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