BenevolentAI Investor Day Presentation Deck
Colon biopsy signatures
pixel intensity (AU)
pixel intensity (AU)
Phosphorylation pattern in...
2000
1800
1600
1400
1200
1000
800
600
400
200
0
20
SENER
EGFRIEDB1
2000
1800
1600
1400
1200
1000
800
600
400
200
0
BR2/E82
EGFRBt81
ER2/ErbB2
FGFR1
FGFR1
FGFR3
FGFR3
FGFR4
FGFR4
InsR
IGF-IR
TrkA/NTRK1
TKB/NTRK2
MetHGFR
Ron MSTIR
InsR
IGF-IR
Tik A/NTRK1
MetHGFR
TikB/NTRK2
Ron/MSTIR
Ret
ALOGFR
ALK
CKISCER
Healthy colon biopsies
PDGFR
kitSCFR
の
SAHIT
M-CSFRICSF-1R
EphA1
EphA2
PLT3/FK2
M-CSFRICSF-IR
del
EphA1
Inflamed Crohn's
biopsies
Eph43
Tyro3/Dik
EphB1
VEGFR2
Aki/PKB/Rac Th308
e2/TEK
Tyro3/Dek
42 MAK
Tie2/TEK
Akt/PKB/R
PKB/Rac T
RK1
S6bos. Protein
0
AktPKB/Rac Ser473
D44/42 MAPK (ERK1/2)
96 dbos. Protein
IRS-1
Zap-70
d
healthy-
healthy
Stat3
Stat1
Lck
Src
-Zap-70
IAS-1
c-Abl
S6 ribos. Protein
p44/42 MAPK (EAK 1/2)
Akt/PKB/Rac Ser473
Akt/PKB/Rac Thr308
-VEGFR2/KDA
Tie2/TEK
HeaTE
Axl
-Tyro3/Dtk
-EphB4
EphB3
-EphB1
Spro
EphA3
EphA2
Pu
-EphA1
MCSE
M-CSFR/CSF-1A
FLT3/FIK2
c-kit/SCFA
PDGFR
ALK
2
Rot
Ron/MSTIR
MovHGFA
TrkB/NTAK2
-TrkA/NTRK1
IGE-IR
INSH
InsA
LEGFR4
FGFR3
FGFA1
HER3/ErbB3
HER2/ErbB2
-EGFA/ErbB 1
56
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