Taysha IPO Presentation Deck

Significant, dose-dependent improvement in survival observed in mice treated with TSHA-101 Survival (%) 100 50 0 0 20 40 60 Time (weeks) 80 100 - - Heterozygote/Vehicle (n=6) Knockout/2.5x10¹1 total vg (n=11) Knockout/1.25x10¹1 total vg (n=6) Knockout/0.625x10¹1 total vg (n=6) Knockout/Vehicle (n=6) * p-value=0.0141 p-value=0.0012 **** p-value<0.0001 * 19

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