23andMe Investor Presentation Deck

10974910 POLI SARI-2 11 Genetic Association of the TSLP Signalling Pathway With Asthma 34 w3170kb 110 1105 Position on ch5 Mb) 113077426 THE ATSAP TOAL 1₂ Position on a Mb W +RAY Position on chr + CONTRA wwx+ 13 1837253 65 AMA PONED ALDE 0 STANDA 1115 4 ASUT 80 TSLPR Cell membrane JAK2 TSLP STAT5 JAK1 Proinflammatory signaling IL-7Ra I T 1 I CHOP 2 -PARC -OHOO 12607352 DAMA T scie Postion on M 12409003 # Ma JANY 849 65 Position on chrt (Mal +1000+CHUN X+ +6241 59° ° ° °CAT 2522 496016. E AARSON NOR -Dw THEN 35.9 WASI NAU HILD compre PANCO rung --00734 MERI RAPPEL TREGON 425 Poction on 17 M 65.1 inge MUNDO Maje COMO WEN an 30 65.2 cocass - AFLAD 43.5 229 2 TSLP is a well-known cytokine with a role in maintaining immune homeostasis and regulating inflammatory responses at mucosal barriers. The TSLP signaling pathway is an attractive therapeutic target. e.g. Tezepelumab, a TSLP-blocking monoclonal antibody for treatment of asthma. Our genetic data shows that multiple genes within the TSLP pathway associate strongly with asthma. Copyright © 2022 23and Me, Inc. 23andMe 33

View entire presentation