Bionomics Investor Presentation Deck
PTSD: A Chronic Psychiatric Disorder with Significant Morbidity and Mortality
PTSD Represents a Significant Unmet Need
A debilitating disorder that leads to social,
occupational and interpersonal dysfunction
PTSD involves flashbacks, intrusive thoughts and
"nightmares
PTSD causes changes in cognition, mood,
arousal and reactivity
PTSD results from exposure to actual or
threatened death, serious injury or sexual violence
Only 20-30% of PTSD patients achieve clinical
remission on SoC SSRI therapy²
Bionomics
1.
Work
Patients may orient their careers around a narrow set of
potential occupations and may struggle with job
performance
3.
Relationships
PTSD can impair trust, closeness, and communication,
leading to difficulty maintaining family and romantic
relationships.
Lifestyle
PTSD-associated poor nutrition, reduced physical activity, and
increased obesity and smoking, increase risk of
cardiovascular and other diseases
Kilpatrick, D., Resnick, H., Milanak, M., Miller, M., Keyes, K. and Friedman, M., 2013. National Estimates of Exposure to Traumatic Events and PTSD Prevalence Using DSM-IV and DSM-5
Criteria. Journal of Traumatic Stress, 26(5), pp.537-547; 2 Mayo LM, Asratain A., Lindé J et al. Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses
Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial. Biol Psychiatry. 2020 Mar 15; 87(6): 538-54
2. Lee DJ, et al. Psychotherapy versus pharmacotherapy for posttraumatic stress disorder: systemic review and meta-analyses to determine first-line treatments. Depress Anxiety.
2016;33(9):792-806.
US Census Bureau. https://www.census.gov/library/stories/2021/08/united-states-adult-population-grew-faster-than-nations-total-population-from-2010-to-2020.html
Quality of Life
PTSD patients avoid people, places, or environments which
may trigger trauma, making daily living difficult
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