Taysha IPO Presentation Deck

451 targets annotated across both species for selected 3'UTRS # of mouse UTRs 11 10 9 8 7 ·6543 2 1 0 O 0 000 0 1 2 3 4 5 6 7 8 9 10 11 # of human UTRs - Many targets appear frequently among the 3'UTRs of dose- sensitive genes mediating disorders characterized by intellectual disability Bounded area: targets appear across 26 selected 3'UTRs Orange data points: corresponding miRNAs expressed in CNS tissue Squares: corresponding miRNAs are potentially MeCP2-responsive T New target panel miRARE • Compact (6 targets) • Useful for RTT .Possibly multipurpose • Translationally relevant MP426 Promoter miniMECP3-myc 51

View entire presentation