AstraZeneca Investor Day Presentation Deck

FACT-P quality of life over time Quality of life comparable between treatment arms Least-squares mean change from baseline in FACT-P total score* 20 15 10 5 0 -5 -10 -15 -20 H PH 5 Least-squares mean change from baseline in FACT-P total score* 41 45 49 53 Analysis visit (weeks) 9 13 17 21 25 29 33 37 → Olaparib + abiraterone (n=399) Placebo + abiraterone (n=397) 61 69 77 85 93 101 109 117 *Plot includes 95% confidence limits. FACT-P total score change from baseline values can be a minimum of -156 and a maximum of 156. A clinically meaningful change in FACT-P total score is 1015,16 34 FACT-P = Functional Assessment of Cancer Therapy-Prostate. B

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