Ocuphire Pharma Investor Updates
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Presbyopia Eye Drops Competitive Landscape
Validation of Pupil Modulating Drops Achieving Pin-Hole Effect & Efficacy, Many with Pilocarpine
Pupil modulation MOA
Soften lens MOA
Combination drugs
*act on sphincter and
ciliary muscles in dose-
dependent manner
Cholinergic
Agonist*
(pilocarpine)
Other Cholinergic
Agonists*
Visus
(BrimocholⓇ;
brimonidine +
carbachol)
Orasis
(CSF-1;
Low dose pilo)
Allergan
(AGN-190584;
1.25% pilo)
Eyenovia
(MicroLine;
1 or 2% pilo)
NDA
Phase 3
Phase 2
Phase 1
Lenz
(PRX-100;
aceclidine)
Novartis
(EV-06)
Ocuphire
(0.75% Nyxol +
0.4% pilo)
Ocuphire is differentiated by using both
the dilator and sphincter muscles
moderately to reach a pin-hole pupil size
Alpha Antagonist
& pilocarpine*
Corporate Websites, Grzybowski, A, Markeviciute A, Zemaitiene R. A Review of Pharmacological Presbyopia Treatment. 2020
Ocuphire
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