BioNTech Investor Day Presentation Deck
BNT151
Stimulates CD8+ and NK cells, without extensively triggering Treg cells
BNT151 design
●
●
IL-2RB
human IL-2 (hlL2)
IL-2Ra
IL-2Ry
high affinity
Regulatory T cells
medium affinity
Effector T cells
BNT151
BNT151
medium affinity
Regulatory T cells
• Increased binding to IL-2RB
●
attraction
= repulsion
Weakened binding to IL-2Ra
Designed to stimulate naïve and effector T cells with
low to no expression of IL-2Ra (CD25 low/neg) without
extensively triggering immunosuppressive regulatory T
cells
Vormehr M, et al. SITC Annual Meeting 2019; Poster presentation 626.
high affinity
Effector T cells
B
BNT151 mediates increase of effector CD8+ to Treg ratio
A
Tetramer* CD8*
cells per ul blood
15-
10-
0
α-PD-L1:
BNT151.
254
CD8+ T cells
20-
15-
Adpgk specific CD8+ T cells
ns
+
Control
****
+
z
BNT151
****
15-1
10-
NK cells
Control
****
BNT 151
1.6-
1.5-
1.4-
1.3-
1.2-
1.1-
1.0-
Tregs
ns
P
Control
BNT151
NUMM
B CD8* to Treg ratio
20-
Control
BNT151
RiboCytokines
BIONTECH
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