BioNTech Investor Day Presentation Deck

Manufacturing and automation iNeST manufacturing innovation: Cycle-time reduction with automated process 3 4 5 A BAROD A ET 17 1 Individual patient samples (blood and tissue) NORMAL 2 GGGAAACTTTTTCC TUMOR GGGAAACG TTTTCC Weeks Mapping of mutations Neoantigen prediction On-demand tailored RNA manufacturing Manual process (until 2016) 6 1Σ2 Σ3 Σ4 Σ 5 Needle to needle: >3 months Weeks >1 Σ2 Σ34 5 7 Targeting delivery: <5 weeks Individualized immunotherapy Semi-automated process (from 2017) 6 8 8 9 9 10 11 12 13 10 11 12 13 BIONTECH 52

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