Absci Investor Presentation Deck

Antibodies selected in tertiary lymphoid structures bind to cancer cells and are associated with favorable clinical outcomes B cell Follicular dendritic cell 10 74 Tumor Plasma cell T cell Macrophage LO Tertiary Lymphoid Structures (TLS) are centers of immune activity (B-cell proliferation and antibody production) that develop in chronically inflamed tissues such as tumors. 00 Meylan, Maxime, et al. "Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer." Immunity 55.3 (2022): 527-541. ABSCI CORPORATION 2023 ALL RIGHTS RESERVED ● Progression-free (%) 100 75 50- 25- 000000 P= 0.019 10 Time High Ig Staining +++ Low Ig Staining 15 20 The presence of TLS is associated with longer progression-free survival and better response to immune checkpoint inhibitors. • Rapidly growing evidence illustrates correlation between TLS- derived antibodies in the tumor microenvironment and positive clinical outcomes. ● • TLS-derived antibodies have been shown to be associated with apoptosis of cancer cells in patients. absci. 30

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