Comera Investor Presentation Deck

● ● mAb A liquid formulation optimization by DOE Isothermal stability studies for optimizing m Ab A formulation Set up isothermal hold studies at 40C for 4 weeks mAb A: 150 mg/ml Sugars total conc: 200-500 m M Formulation A B ● CDEFGH ● с Н J pH 7 5 6 6 6.5 7 7 5 6.5 5 Recommended Formulation: mAb A conc (150 mg/ml) 5 mM phosphate buffer, pH 6.5 350 mM sugar mix Sugars (mm) 500 500 200 350 500 350 200 350 350 500 monomer 80 60 40 20 5 5.5 6 pH 100 90 80 70 60 50 40 30 20 10 0 6.5 A B C D E F G H I J DOE samples 7 DOE for formulating mAb A Lower pH detrimental for stability 500 450 350 300 Monomer 60 > 350 mM sugar mix helps stability 15 60 A Comera LIFE SCIENCES 20

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