Absci Investor Presentation Deck

CASE STUDY: DE NOVO DESIGN IN SILICO High sequence diversity supports patent estate expansion and differentiation HCDR3; HCDR3; Designs are sequence diverse from one another, with a mean edit distance of 7.7 ± 2.1 SD ABSCI CORPORATION 2023 ALL RIGHTS RESERVED 14 12 10 CO st Edit distance between pair of HCDR3s Example HCDR3 designs (edit distance) -Log₁0 (KD) SRWG GD GFYAMDY (Wildtype) 8.71 ARWGNYYYYM DY (6) 8.77 ARYYYGFYYFDY (7) 8.92 6.24 9.03 7.0 8.4 7.01 8.02 ARYAGVERPGSFAY (11) TRYFFNGWYYFDV (9) AFADS GAYGIWSF (12) ANDIYIQ GYDLNR (12) ARGYSGDW PYET FYV (10) ARYD Y GYYIY VS (10) Key: Amino acids of the same color belong to the same class absci. 16

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