Bionomics Investor Presentation Deck
A Differentiated Approach: The a7 Nicotinic Acetylcholine Receptor
3
Normalizing Effect Utilizing Allosteric Modulation
2
1
Channel opens:
ACh binds to
a7 receptor
orthosteric
sites
PAMS/NAMS
bind to a7
receptor
allosteric sites
Bionomics
Ca²+ = Calcium ions
ACh = Acetylcholine
Ca2+
Ca²+
NAM = Negative Allosteric Modulator
PAM = Positive Allosteric Modulator
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CIAS = Cognitive Impairment Associated with Schizophrenia
ADHD=Attention Deficit Hyperactivity Disorder
Ca²+ flow
through the
channel when
a7 receptors
are activated
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Transmembrane
Binding Domain
0000000
Allosteric drug
transmembrane binding
domain restores normal
activity
Cholinergic System associated with memory, selective attention, and emotional processing cognitive functions
PTSD = Post-Traumatic Stress Disorder
Hypercholinergic
Disease States
Targeting Distinct CNS Conditions with Neurotransmitter Imbalance
PAM
Indications
Bionomics
NORMAL ACTIVITY
+ Alzheimer's
+ CIAS
+ ADHD
BNC 210 (NAMS)
+ Anxiety
+ PTSD
+ Depression
LO
Hypocholinergic
Disease States
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