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argenx SE Investor Day Presentation Deck slide image

argenx SE Investor Day Presentation Deck

DM and ASyS Autoantibodies Activate Complement and Type 1 Interferon Y Autoantibodies argenx Complement Activation Complement Activation Interferon Production Myolysis Disruption of capillaries 1 1 Dendritic cells produce Type 1 interferon from immune complexes ā— 1 complement 6:5 2 2 2 Type 1 Interferon Impaired myotube formation Impaired angiogenesis: destruction of capillaries and hypoperfusion Necrosis Hypoperfusion Increased autoantibody production Necrosis Atrophy 27
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