Kymera IPO Presentation Deck

Co-opting a Naturally Occurring Process to Regulate Protein Levels 1 2 3 KYMERA E3 ligase recognizes protein Ubiquitin chain transferred Protein is marked for elimination Broad Opportunity Only Binding Site Required Efficient Catalytic Targeted Protein Degradation Biology Prolonged Impact Targeted Protein Degradation E3 1 Disease-causing Target Protein Degrader E2 Peptides from Degraded Protein Ubiquitin 3 Proteasome 2 Targeted Small Molecule Protein Degraders Ubiquitin Chain

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