Taysha IPO Presentation Deck

Vagus nerve injection of increasing doses of AAV delivery were well-tolerated in hounds observed over 13 days Body Weight (lbs) 60 Testing VN Delivery Rates High Mid Low Pre-surgery Day of 2 Weeks 1 Week Surgery Post-surgery Post-surgery Post-mortem vagal nerves and brain were microscopically normal Amount of Feces Post-surgery Afternoon Fecal Output Post-surgery Vocalization Day High Mid Low High Mid Low Taysha has exclusive rights to the vagus nerve redosing platform in select indications. Hannah's Hope Foundation owns the rights to the Giant Axonal Neuropathy program. 48

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