BioAtla IPO Presentation Deck
BA3011 AXL-ADC Phase 2 Clinical Program
Potentially Registration-Enabling Phase 2 Trials (RP2D: 1.8mg/kg Q2W)
STS
Bone
sarcoma
STS & Bone
sarcoma
Phase 2 - Sarcoma-mono and/or combo with PD-1;
BA3011 dose: 1.8mg/kg Q2W; AXL TmPS 270; 3rd line n=165-240
BA3011 Monotherapy (n=40)
BA3011 Monotherapy (n=30)
Combo with PD-1 (n=20)
CD20 positive and negative
Phase 2 NSCLC
mono & combo with PD-1 in PD-1
exposed patients (n=20)
Timeline
Sarcoma:
• 3rd line patients (chemotherapy failure)
Interim
analysis
Selected ST5 & bone subtypes (n-150)
mono &/or combo w PD-1
AXL positive
Primary endpoint: ORR
Matching population synthetic arm
Phase 2 Population
Proof Of Concept read-out (POC)
Secondary endpoints: "PFS; OS
Data
read-out
Ovarian Investigator-Initiated Trial (IIT) not shown
NSCLC:
• Prior disease progression on PD-
1/L1 inhibitor
Note: "TmPS= Tumor membrane Percent Score-Scores range from 0 to 100; "PFS progression-free survival, OS = overall survival
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