Comera Investor Presentation Deck

Effect of stabilizers on Isothermal stability of mAb ● ● ● ● % monomer remaining 100 95 90 85 BO 75 70 65 60 allill CS1 No stabilizer CS3 Pembrolizumab 4 week monomer loss study 5 mg/ml mAb C54 Stabilizers saccharide conc: 0.2M Sucrose Treh CS2 MT4 % monomer remaining 100 95 90 85 80 75 70 65 60 Control CS3 Nivolimumab 4 week Monomer loss study MI Sucrose CS1 mAbs were formulated with the stabilizers and isothermally incubated at 40C for 4 wk CS4 Stabilizers All stabilizers were effective in improving thermal stability as compared to no stabilizer control Treh CS2 T4 Comera LIFE SCIENCES 12

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