Comera Investor Presentation Deck
Effect of stabilizers on mAb thermal stability
Ellipticity change
2
Ellipticity change
1
0
-1
35
7
6
5
0
-1
Nivolimumab Thermal Melt
-Ctrl
-CS1
CS4
CS3
-Sucrose
<-CS1
<-Cs3
-CS4
<-Suc
45
control
20
Temp (C)
75
pembrolizumab Thermal Melt
Temp (C)
80
85
100
Ellipticity change
8
Normalized Ellipticity
7
6
NHO5
-1
20
15
10
UT
5
-10
- Ctri
<-CS4
-CS1
20
CS3
-Sucrose
ctrl
CS1
-CS3
-CS4
30
Trastuzumab Thermal Melt
45
55
65
Temp (C)
40
Ustekinumab CD thermal melt
50
60
Temp (C)
^
75
70
85
80
95
90
ā
ā
Stabilizers validated with CD thermal
melt
Comera
LIFE SCIENCES
mAb conc: 0.2 mg/ml mAb
Stabilizer conc: 20 mM
Temp ramp 1C/ min
Novel stabilizers improve the
thermal stability by shifting melting
temp
Thus they appear to be similar or
better than sucrose in stabilizing
mAbs against thermal stress
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