Kymera Results Presentation Deck

Mean % Change in Peak Pruritus (+/- S.E. of Mean) 0 -10 -20 -30 -40 -50 -60 -70 -80 -90 -100 KYMERA 0 Peak Pruritus NRS: Mean 62 to 68% Reduction -29.1 7 Mean % Change in Peak Pruritus Over Past Week -17 -41.7 Ⓒ2022 KYMERA THERAPEUTICS, INC. 14 -26.1 -41.9 -All HS (N=12)* *One patient is censored for Day 35 and Day 42 since the patient started on ustekinumab, steroids and abx on Day 34. -24 21 Day -67.8 28 Moderate to Severe (N=10) -48.6 -62.3 35 -53.6 -61.6T -68.4 42 PAGE 55

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