Conference Presentation

Features and Benefits of Reduced Nicotine Cigarettes Proprietary Technology in Reduced Nicotine Content Science-Backed Research from Clinical Trials VLNⓇ cigarettes contain 95% less nicotine than conventional cigarette alternatives We own or control over 200 issued and pending patents and other intellectual property related to nicotine biosynthesis in tobacco plants Since 2011, our reduced nicotine tobacco has been used in more than 50 independent scientific clinical studies conducted by researchers at universities and institutes These studies have been largely funded by U.S. government agencies and are estimated to have cost over $100 million ● ● ● Ž Discernable Adult Smoker Benefits Reduce nicotine exposure and dependence Smoke fewer cigarettes per day Experience reduced withdrawal symptoms Increase number of smoke-free days Double quit attempts STUDIES SUPPORT 22ND CENTURY'S PMTA & MRTP APPLICATIONS AS WELL AS THE FDA'S PROPOSED PLAN TO REDUCE NICOTINE LEVELS IN ALL COMBUSTIBLE CIGARETTES Sources: Eric C. Donny, Ph.D., Rachel L. Denlinger, B.S., et al. "Randomized Trial of Reduced-Nicotine Standards for Cigarettes." Oct. 2015. Dorothy K. Hatsukami, PhD; Xianghua Luo, PhD, et al., "Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure." Sept. 2018. Dorothy K Hatsukami, Michael Kotlyar, et al., "Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation." Feb. 2010. 22nd Century Group, Inc. 11

View entire presentation