Kymera Investor Day Presentation Deck
Criteria
• Availability of
●
Approaches
●
Virtual Screen
●
A Comprehensive Hit Finding Toolbox Rapidly Enables
New Ligand Discovery Against All Target Classes
structure or
homology model
DB ~8 million
purchasable cpds
Cloud enables screen
< 24hrs
Al to improve
enrichment
KYMERA
H
●
DEL
Criteria
High quality protein
Ideal QC profile
(single-species by
SEC; <5%
aggregation by DLS)
©2021 KYMERA THERAPEUTICS, INC.
Criteria
Availability of high
quality
(crystallization-grade)
Ⓡ
Fragment-Based
Screen
●
Approaches
SPR, NMR
X-ray
LC/MS (covalent)
●
protein
Robust crystallization
system
Cysteine Covalent
Screening
Criteria
Proteins have
reactive cysteines
•
Approaches
• Covalent fragment
screening on
recombinant protein
• Whole cell covalent
fragment screening
KYMERA R&D DAY - December 16th, 2021
HTS
Criteria
Available high-
throughput assay
format
Approaches
Focused library
Diversity set
●
IM)
ASMS
Criteria
• Availability of high-
quality protein
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