Akouos IPO Presentation Deck

Overview of Genetically-Driven Hearing Loss • Tens of millions of children with monogenic hearing loss worldwide • Congenital hearing loss recognized as neurodevelopmental emergency by American Academy of Pediatrics . • Some of the most common forms of monogenic deafness affect an estimated ~200,000 individuals in the U.S. and Europe 11 No drugs currently approved for the treatment of sensorineural hearing loss 1 of 500 newborns has disabling hearing loss Complex Etiology (20%) Recessive (80%) Genetic Causes (80%) Nonsyndromic (75-80%) Dominant (19%) Syndromic (15-20%) Mitochondrial & X-Linked (1%) Autosomal Recessive Autosomal Dominant Note: Syndromic hearing loss means, in addition to hearing loss, the individual has other symptoms of medical importance CONFIDENTIAL Nonsyndromic AKOUOS >75 genes >48 Syndromic >30 genes >10

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