BioNTech Investor Day Presentation Deck
1 Neoantigen prediction
New Al-based immune response model may improve accuracy of prediction
Trained to enable an integrated view of immune
response features i.e.
Biochemical features
Physical (structure-based) features
Eluted ligand (also predicted by NetMHCpan)
Transcript expression
●
●
Al-based immune response model
incorporates new features
●
Predicted immunogenicity of 3980 targets compared to
NetMHCpan EL model
EL, eluted ligand; ROC, receiver-operator-characteristics.
Lang M, et al. CIMT Annual Congress 2022; Poster presentation 21.
ROC curve for the Al-based immune response model
and NetMHCpan 4.1 EL-based evaluation
True positive rate
1.0
0.8
0.6
0.4
0.2
0.0
0.0
0.2
Immune Response Model
NetMHCpan 4.1 EL
0.4 0.6
False positive rate
New features significantly improved immune response prediction across
data from >100 publicly available resources vs NetMHCpan EL
Digital & AI/ML
0.8
1.0
InstaDeep™ BIONTECH
42View entire presentation