Comera Investor Presentation Deck

mAb liquid formulation development: Buffer screening Rh (nm) 50 45 40 35 30 25 20 15 10 5 ● ● M DLS screen Makan Varferz hiff rettent Many 5 10 time (h) 15 20 -pH 6 his -pH 6 MES pH 5.5 Ac buffer -pH 7.5 PB -pH 6 his pH 5 citrate -pH 7.0 PB -pH 6.5 his -pH 6.5 MES -pH 5.0 Ac buffer -pH 6,5 5 PB 100 80 60 40 20 0 11 ctrl Accelerated stress screen DLS and BLI octet screening to identify pH and buffer Short Accelerated isothermal hold stress screening for 1-2 week Phosphate buffer was observed to improve stability Phos pH 7 Acet pH 5.5 Comera LIFE SCIENCES Phos-Ac pH 6 ■0 wk ■2wk 16

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