Comera Investor Presentation Deck

mAb liquid formulation development: viscosity screen Binding (nm) 2.5 2.0 1.6 10 0.5 -0.5 -10 Self Assn 550 600 Sensor A6 Self Assn MES buffer pH 6 Phos buffer pH 6 660 BLI octet screen 700 750 800 Sensor C6 His buffer pH 6 Acetate buffer pH 6 850 Time (sec) His buffer pH 6 VR His buffer pH 6 Phos buffer pH 6 VR +Phos buffer pH 6 900 950 Sensor E6 1000 1050 Dissn HE 1100 Sensor G6 Dissn 11 Viscosity (CPs) 25C 100 90 80 70 60 50 40 30 20 10 0 50 100 150 Concentration (mg/ml) 200 Comera LIFE SCIENCES 250 DLS, BLI octet and microvisc help to identify and validate viscosity reducing excipients 17

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