BioNTech Investor Day Presentation Deck

1 Neoantigen prediction Digital & AI/ML Genomic and ligandomic expertise drive our individualized-target database Neoantigen Gene Mutation Length Transcript MHC I MHC II rank (aa) VAF score score 1 27 16.05 0.1 2 27 1.44 0.04 3 26 2.07 0.28 20 Internal data. SNF8 SEMA7A DUS4L V 183M G340S S305P Characterization of neoantigen peptide Types of mutation and clonality of mutations 2.16 8.6 8.54 Peptide-MHC binding affinity/quality Mutated transcription expression level Coverage VAF Coverage in in tumor in tumor normal tissue 155 0.33 113 0.44 213 0.48 Similarity/richness across tumors 119 120 150 VAF in normal tissue 0.00 0.01 0.00 Lack of expression in healthy tissues BIONTECH 41

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