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Investor Presentation

2022 PRIORITIES & AREAS OF FOCUS Tobacco Franchise 01 Launching VLNⓇ in U.S. and International Markets ■ Launching VLN® Chicago pilot with Circle K ▪ Engaging with multiple retrial trade partners to support national launch capabilities post-pilot ■ ■ 02 Advocating for proposed menthol ban and nicotine cap policies First VLNⓇ international launch in South Korea Ramping manufacturing capabilities ■ FDA progress on menthol ban MRTP positions VLNⓇ as possibly the only menthol cigarette still available Favorable political climate ■ ■ Hemp/Cannabis & Hops Franchises 03 Expanding upstream hemp/cannabis revenue ■ Initiated hemp/cannabis biomass sales and IP licensing activities ▪ Expanding available plant lines for 2022 and 2023 ■ Achieved hemp/cannabis breakthrough in plant transformation 04 Positioning for launch in hops market ▪ Building out commercial partnerships ■ Targeting specific applications and benefits of interest to key hops growers Faster route to commercialization than first two franchises Financial 05 Balance sheet strength to fuel partner-focused commercialization strategy I 22ND CENTURY GROUP ■ $39 million in growth capital to support VLNⓇ national launch ▪ Leveraging partner footprint and marketing capabilities for low-cost, high-impact approach Deploying capital to fuel U.S. VLNⓇ launch, commence international sales of VLNⓇ, accelerate cannabis commercialization, and launch hops franchise 27

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