Kymera Results Presentation Deck

Mean % Change (+/-S.E. of Mean) -10 -20 -30 -40 -50 -60 -70 -80 O -5.8 KYMERA TF 7 Mean % Change in Peak Pruritus Over Time (N=7) -6.6 Peak Pruritus NRS: Mean 52 to 63% Reduction Peak Pruritus NRS Responders: 57 to 71% -32.1 14 -34.6 -43 -35.6 -51.2 21 Day I ©2022 KYMERA THERAPEUTICS, INC. -44.6 28 Past 24 Hours ➡Past Week -38.9 -44.6 35 -51.9 -62.9 42 % of Peak Pruritis Responders (80% CI) 100 90 80 70 60 50 40 30 20 10 0 0 % of Patients with 24 Unit Reduction from Baseline in Peak Pruritus (N=7) 7 29 14 43 Past 24 Hours 29 21 Day 71 57 28 Past Weel 57 35 43 71 57 42 PAGE 47

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