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VLNⓇ Path to Commercialization The FDA Pathway to MRTP Commercial Readiness Submit Premarket Tobacco Product Application (PMTA) to the FDA December 4, 2018 ✓ Submit Modified Risk Tobacco Product Application (MRTPA) to the FDA May 17, 2019 ✓ The FDA accepted and filed MRTPA for substantive scientific review July 19, 2019 PMTA authorized by the FDA December 17, 2019 "Authorizing these reduced nicotine products for sale in the U.S. is appropriate for the protection of public health" - The FDA press release on 12/17/19 MRTPA public comment period close May 18, 2020 MRTP Authorization by the FDA IN "FINAL ACTION" STAGE *These advertisements were submitted to the FDA as an exhibit to the Company's MRTP application for VLN. ● ✓ The FDA's Tobacco Products Scientific Advisory Committee (TPSAC) review of MRTPA February 14, 2020 Go-to-Market Strategy After the FDA authorizes 22nd Century's MRTP application, VLNⓇ will be registered with each state to enable national commercialization • 22nd Century will initially launch VLN® though a targeted pilot rollout program across select U.S. geographies • 22nd Century manufactures its reduced nicotine content cigarettes in a 62,000 sq. ft. manufacturing facility, which also contract manufactures third-party brands Contains 95% less nicotine than conventional cigarettes* VLN VLN 95% LESS NICOTINE Helps dace your cumption VLN Nicotine is addictive, Less nicolare does NOT mean safer. All cigaretten can cause disease and death. 95% LESS NICOTINE If you smoke, consider VLN™ VLN™ smells, burns, and tastes like a conventional cigarette, but greatly reduces your nicotine consumption Learn more at vincigarettes.com 95% LESS NICOTINE nicotine consump * VLN Helps reduce nicotine consumption SURGEON GENERAL'S WARNING: Cigarette Smoke Contains Carbon Monoxide. 22nd Century Group, Inc. MAKE THE SWITCH to 95% Less Nicotine REAL TOBACCO VLN smells, burns, and tastes like a conventional cigarette, but greatly reduces your nicotine consumption For the nearest retailer, visit vincigarettes.com/stores or call: 800-225-1838 ext. 221 % LESS NICOTINE VLN Nicotie is addictive as nicotina does NOT safer A ciganes can cause disease and death SURGEON GENERAL'S WARNING: Cigarette Smoke Contains Carbon Monoxide. Smells, burns, and tastes like a conventional cigarette * 12

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