AstraZeneca Results Presentation Deck

Appendix: 'What's next' Next key milestone by project Oncology Project adavosertib ceralasertib oleclumab AZD4635 AZD4573 MEDI5752 MEDI2228 AZD2811 AZD5991 AZD0466 Status as of 11 February 2021. 38 Target WEE1 ATR CD73 A2AR CDK9 PD-1/ CTLA4 BCMA Aurora B MCL1 Bcl-2/xL Phase || || || 11 || | 1 I I | Indication uterine, ovarian cancer solid tumours blood cancers solid tumours solid tumours blood cancers solid tumours blood cancers solid tumours blood cancers blood cancers solid tumours blood cancers Next milestone Phase III start Phase II data Phase II data Phase II data Phase II data Phase II start 2021 Phase II start 2021 Phase II start 2021 Phase II start 2021 Phase I data 2021 Phase I start 2021 BioPharmaceuticals: CVRM Target GLP-1/ glucagon Project cotadutide AZD4831 AZD5718 AZD9977 + Farxiga zibotentan + Farxiga AZD2693 AZD8233 MEDI3506 AZD1402 AZD0449 AZD4604 MPO MEDI7352 FLAP MCR + SGLT2 ETR + SGLT2 PNPLA3 PCSK9 IL33 IL4Ra JAK Phase NGF TNF || || || I I || BioPharmaceuticals: Respiratory & Immunology I || | | Indication 1/11 NASH DKD HFpEF CKD CAD HF with CKD CKD NASH dyslipidaemia COPD asthma, AD, COVID-19, DKD asthma asthma Pain Next milestone Phase IIb data H2 2021 Phase II data 2022 Phase IIb start H1 2021 Phase Ilb data 2022 Phase lla data H1 2021 Phase II start H1 2021 Phase II start H1 2021 Phase I data H2 2021 Phase II data H2 2021 Phase I data 2021 Phase II data through 2021 Phase II start H1 2021 Phase II start H1 2021 Phase I start H1 2021 Phase II start, Phase II data 3

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