23andMe Investor Presentation Deck

CD200R1 is an Immune Checkpoint CD200R1 is an inhibitory receptor expressed on T-cells and myeloid cells CD200 is the only known ligand for CD200R1 in humans and is highly expressed in certain cancers Binding of CD200 to C200R1 decreases the ability of T-cells to recognize and kill cancer cells Several viruses have co-opted CD200 analogues to suppress and evade the host immune response References: J Virol 2012;86:6246, J Virol 2004;78:7667, J Immunol 2005;175:4441, Structure 2013;21:820, JCI Insight 2018;3:e96836 Tumor cell CD200:CD200R1 Signaling 000 CD200 Reduced antitumor immune response CD200R1 Immune cell OOOPPP DOK2 RasGAP ERKRas Nat Akt Copyright © 2022 23and Me, Inc. 23andMe 40

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