23andMe Investor Presentation Deck

PD-1, CD96 and TIGIT are Negative Regulators of CD226 Axis Combining inhibitors may enhance anti-cancer activity - Activating/co-stimulatory interaction - Inhibitory interaction CD112 PVRIG APC/Tumor TIGIT CD155 PD-L1 CD226 CD96 PD-1 T/NK cell ● ● CD226 activates NK/T-cells PD1 directly regulates CD226 activity TIGIT and CD96 indirectly suppress CD226 Combining inhibitors (anti- PD-1, anti-CD96, anti-TIGIT) may have more activity that anti-PD-1 alone Copyright © 2022 23and Me, Inc. 23andMe 39

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