Ocuphire Pharma Investor Presentation Deck

ASRS PAT Survey: Majority of Physicians Use a "Wait and Monitor" Approach for DR NPDR Patients Are Not Treated Proactively and Anti-VEGF Use is Limited Ocuphire How do physicians treat patients with severe NPDR without DME? Closely monitor retinopathy and encourage systemic glycemic control Consider anti-VEGF in some patients with poor glycemic control and/or other risks Consider anti-VEGF in some patients with good glycemic control and compliance Consider anti-VEGF therapy in all or most patients ASRS 2021 Preferences and Trends (PAT) Survey Other 0% 4.9% 3.1% 7.7% 7.8% 10% International 10.9% 3.7% US 20% 17.0% 24.9% 30% 40% 50% 59.5% 60.5% 60% 70% 10

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